Hydroxocobalamin is newly approved in the US and is available in Cyanokit antidote kits. Allergic reactions including angioneurotic edema have also been reported in postmarketing experience.Cases of acute renal failure with acute tubular necrosis, renal impairment, and urine calcium oxalate crystals have been reported. We comply with the HONcode standard for trustworthy health information - Consider alternative therapies, if available.Allergic reactions may include: anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, and rash. Regular monitoring of renal function, including but not limited to blood urea nitrogen (BUN) and serum creatinine, should be performed for 7 days following CYANOKIT therapy.Many patients with cyanide poisoning will be hypotensive; however, elevations in blood pressure have also been observed in known or suspected cyanide poisoning victims. Boric acid and/or Sodium Hydroxide are added during manufacture to adjust the pH. The Cyanokit® is a 5-gram vial of hydroxocobalamin for injection, paired in a boxed kit with an IV administration set and 1 transfer spike. Consideration should be given to decontamination measures based on the route of exposure. 2 Vials of Sodium Thiosulfate Injection, USP, 12.5 g in 50 mL of Water for Injection. The Cyanokit® is a 5-gram vial of hydroxocobalamin for injection, paired in a boxed kit with an IV administration set and 1 transfer spike. These elevations were generally transient and returned to baseline levels within 4 hours of dosing. 85 This amount is below levels expected to affect significant exposure to carbon monoxide alone. When shipping ground you can expect the following transit time (business days) to your location. Consideration should be given to decontamination measures based on the route of exposure. Therefore, these and other drugs should not be administered simultaneously through the same intravenous line as hydroxocobalamin.Simultaneous administration of hydroxocobalamin and blood products (whole blood, packed red cells, platelet concentrate and/or fresh frozen plasma) through the same intravenous line is not recommended. DESCRIPTION: Each Cyanide Antidote Package contains: 2 Ampoules Sodium Nitrite Injection, USP, 300 mg in 10 mL of Water for Injection. The presence of cyanide poisoning, defined by a pretreatment blood cyanide concentration ≥39 µmol/L was confirmed in 42 of the 63 patients with evaluable data (67%). Consider alternative therapies, if available.Allergic reactions may include: anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, and rash.
In West Virginia: "Cyanide antidote kit must be kept in immediate work area. Antidotes for Cyanide Poisoning . Monitor blood pressure during treatment with CYANOKIT.Because of its deep red color, hydroxocobalamin has been found to interfere with colorimetric determination of certain laboratory parameters (e.g., clinical chemistry, hematology, coagulation, and urine parameters).Also because of its deep red color, hydroxocobalamin may cause hemodialysis machines to shut down due to an erroneous detection of a "blood leak." In some situations, hemodialysis was required to achieve recovery. A Cyanide antidote kit MUST be rapidly available and ingredients replaced every 1 to 2 years to ensure freshness."
Enable JavaScript to visit this website. In the hospital, a common treatment is the Cyanide Antidote Kit. Allergic reactions including angioneurotic edema have also been reported in postmarketing experience.Cases of acute renal failure with acute tubular necrosis, renal impairment, and urine calcium oxalate crystals have been reported. NDC# 11704-0370-01. There are risks to the pregnant woman and fetus associated with untreated cyanide poisoning. Hydroxocobalamin binds to cyanide, creating nontoxic cyanocobalamin, allowing the body to use oxygen again. ), orders for dealers/resellers, orders under $175.00 and all orders outside the contiguous United States. In animal studies, hydroxocobalamin administered to pregnant rats and rabbits during the period of organogenesis caused skeletal and soft tissue abnormalities, including alterations in the central nervous system, at exposures similar to human exposures at the therapeutic dose.Breastfeeding is not recommended during treatment with CYANOKIT.For medical questions concerning Meridian products, to report an adverse event, or to speak to a member of Pfizer US Medical Information, please call You are encouraged to report side effects of prescription drugs to the FDA.The product information provided in this site is intended only for residents of the United States.